Spatial Profiling Technology
Reveal tissue-level biology with spatially resolved transcriptomics.
Add Context to Your Research with Localized Gene Expression Profiling
Capturing the spatial organization of gene expression across tissue has traditionally been difficult to attain at high resolution. Broad Clinical Labs’ Spatial Profiling Technology services bring spatial context into sharp focus, resolving RNA expression within intact tissue and enabling researchers to better understand how distinct cell types interact, respond to therapeutic intervention, and contribute to disease progression.
Visualize RNA expression at a subcellular level within tumor or immune microenvironments for high precision biomarker identification and characterization.
Probe hybridization and fluorescence imaging detect and map individual RNA transcripts in situ, preserving the spatial context critical for understanding tissue microenvironments and cellular dynamics.
In Situ Spatial Profiling Service
Detect and map targeted RNA expression at the subcellular level directly within fresh frozen and FFPE tissue sections with our 10x Genomics Xenium spatial technology service. This in situ imaging approach preserves native tissue architecture, enabling single cell spatial detection with pre-designed and custom panel options. Two Xenium chemistries are available to match your research objectives.
Xenium v1
Targeted profiling of up to 480 genes with high sensitivity, designed for hypothesis-driven studies where specific genes or pathways of interest have been identified.
Xenium Prime
Broad profiling of up to 5,000 genes with up to 100 targeted add-ons, designed for unbiased discovery applications across complex tissue biology.
Coming Soon
We are expanding our spatial transcriptomics capabilities with the next-generation 10x Genomics Atera and Illumina StrataMap platforms, delivering whole transcriptome coverage at ultra-high sensitivity.
Accelerate Your Spatial Biology Discovery
Research Applications of Spatial Profiling
Disease Progression and Pathology
- Tissue microenvironment characterization
- Spatially distinct cell populations
- Disease stage mapping
- Biomarker development
- Cell-to-cell interactions
Developmental Biology
- Cell fate tracking
- Organ development dynamics
- Developmental tissue organization
- Tissue atlas construction
Drug and Perturbation Response
- Spatial drug response assessment
- Perturbation effect profiling
- Treated vs. untreated comparison
- Target discovery
Spatial Profiling with Broad Clinical Labs
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Spatial Profiling Technology |
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Project Workflow: Spatial Technology
Project onboarding
Quoting
Study design consultation
Sample preparation
Sample sectioning
Fresh frozen or FFPE sections mounted on Xenium slides
Probe hybridization
Probe hybridization on prepared tissue
Imaging
Imaging on the Xenium Analyzer
Data and report delivery
Raw files, QC metrics, and cell-by-gene matrices
Data delivery via cloud-based platform (Manifold.ai, Terra, GCP, AWS S3)
Project onboarding
Quoting
Study design consultation
Sample preparation
Sample sectioning
Fresh frozen or FFPE sections mounted on Xenium slides
Probe hybridization
Probe hybridization on prepared tissue
Imaging
Imaging on the Xenium Analyzer
Data and report delivery
Raw files, QC metrics, and cell-by-gene matrices
Data delivery via cloud-based platform (Manifold.ai, Terra, GCP, AWS S3)