Single Cell Sequencing

Unravel the cellular complexities underlying disease with high-precision single cell insights that power actionable discoveries.

Decode Cellular Diversity with Flexible Single Cell Sequencing Solutions

Cellular heterogeneity holds the key to understanding disease progression, but traditional bulk sequencing obscures these critical differences by averaging the very diversity that drives disease mechanisms and therapeutic resistance. Broad Clinical Labs’ Single Cell Sequencing solutions provide a high-resolution map of each individual cell’s unique profile with automated processing and flexible platform options.

Unlock single cell resolution to decode complex disease architecture—ideal for developing targeted therapies and predicting patient treatment responses.

Service Offerings

Single Cell Gene Expression (GEX)
3′ or 5′

10x Genomics

Profile gene expression across thousands of individual cells with flexible 3′ or 5′ transcript targeting. Enhance your analysis with optional feature barcoding for cell surface proteins or T/B cell enrichment for immune cell investigations.

Single Cell Multiome (ATAC-Seq + Gene Expression)

10x Genomics

Simultaneously capture transcriptomic and epigenetic information from one sample. Reveal deeper insights into cell states and regulatory mechanisms with this integrated platform that combines Assay for Transposase Accessible Chromatin (ATAC-seq) and Gene Expression.

Need help navigating multiome data analysis?

Let our expert bioinformatics team transform your raw multiome data into actionable insights with our optional analysis service.

Unlock Novel Biological Insights with Expert Single Cell Sequencing Solutions

Diverse Platform Solutions

Access our full suite of cutting-edge single cell sequencing platforms to support your specific research goals—from high-throughput profiling to full-length transcript analysis.

Sample Flexibility

Our services accommodate a wide range of sample types including fresh frozen tissue, PBMCs, blood, tumor tissue, and archived specimens, with specialized protocols optimized for each sample format to ensure high-quality data.

Precision Processing & Quality

Expert processing and fully automated workflows minimize sample loss from even the most challenging samples while ensuring optimal cell viability, maximum data yield, and reproducible results for projects of any scale.

Support from Industry Leaders

Leverage over 30 years of genomics expertise with end-to-end support, proven workflows, and access to the latest platform innovations to keep your research at the forefront of cellular genomics.

Single Cell Applications Transforming Research

Advance breakthrough discoveries in oncology, immunology, neuroscience, and developmental biology with single cell insights that reveal the cellular mechanisms driving complex biological processes.

Drug Discovery & Development

Cancer & Tumor Biology

Disease Mechanisms & Pathways

Single Cell Sequencing with Broad Clinical Labs

Service	Data Deliverables	What’s Included
Single Cell Gene Expression (GEX) 3′ or 5′ 10x Genomics	BCL or FASTQ files	GEM creation from cell or nuclei suspension cDNA generation, library construction, & QC Sequencing Data delivery via cloud-based platform
Single Cell Multiome (ATAC-Seq + Gene Expression) 10x Genomics	Raw BCL files Expert analysis available on request	Sample preparation, including 10x Chromium run, library construction, & QC Sequencing Data delivery via cloud-based platform Sequencing performed in full flowcell units, scaled to batch size

Project Workflow- Single Cell Sequencing Services

Project onboarding
(contracting if required)

Regulatory Review
Quoting
Sample Kits

Sample intake and QC
(extraction optional)

Sample Receipt
Incoming visual QC

Library construction

10x Single Cell Gene Expression (3’ or 5’)

10x Genomics Single Cell Multiome (ATAC-Seq + Gene Expression)

Sequencing

Illumina^® sequencing technology (system and flowcell type varies depending upon target sequencing coverage)

Data and report delivery
(bioinformatic analysis optional)

Data delivery to customer-owned cloud location in Google Cloud or Amazon Web Services; or Terra Workspace

Project onboarding
(contracting if required)

Regulatory Review
Quoting
Sample Kits

Sample intake and QC
(extraction optional)

Sample Receipt
Incoming visual QC

Library construction

10x Single Cell Gene Expression (3’ or 5’)

10x Genomics Single Cell Multiome (ATAC-Seq + Gene Expression)

Sequencing

Illumina^® sequencing technology (system and flowcell type varies depending upon target sequencing coverage)

Data and report delivery
(bioinformatic analysis optional)

Data delivery to customer-owned cloud location in Google Cloud or Amazon Web Services; or Terra Workspace

Broad Clinical Labs: At the Forefront of Single Cell Innovation

Our 30 years of genomic leadership and mission to advance research innovation has enabled cutting-edge collaborations that transform how researchers approach cellular analysis and discovery.

Enabling Large-Scale Discovery

We have partnered with Illumina to advance the ambitious 5 billion single-cell atlas project, enabling researchers to process single-cell samples at unprecedented scale and unlock breakthrough discoveries in disease research.

Pioneering Sequencing Applications

Collaborating with Roche, BCL is developing groundbreaking single-cell applications of Roche’s next-generation Sequencing By Expansion (SBX) technology, focusing on rapid, scalable sequencing solutions that transform clinical genomics.

Read about our 4 hour rapid WGS collaboration!

Clinical Services