Microbial Whole Genome Sequencing

Accelerate microbial discovery with high-throughput multiplexed sequencing that delivers publication-ready results.

Start Your Microbial WGS Project

Reveal Microbial Diversity and Function with Microbial WGS Solutions

Microbial genome analysis defies standardization, requiring flexible solutions that can navigate varying GC content, sample complexity, and evolving research objectives with equal precision. Advance your research with Broad Clinical Labs’ Microbial Whole Genome Sequencing, where customized library construction and high-throughput multiplexing technology deliver publication-ready data tailored to your unique research.

Our Microbial WGS solutions include both tagmentation-based and non-tagmentation-based library construction to optimize data quality across diverse sample types, enabling adaptable workflows that advance multiple research areas.

Tagmentation-based

Metagenomic & Isolate

Efficient multiplexing approach ideal for complex metagenomic communities and large genome bacterial isolates, supporting high-throughput analysis of low-input samples.

Non-tagmentation-based

Plasmodium & Fungal

Optimized for low-GC bacterial isolates, providing enhanced coverage uniformity for high-quality whole genome assembly.

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Flexible, Scalable Solutions for your Genomic Studies

Flexible Library Construction

Tagmentation-based and non-tagmentation-based library construction supports diverse microbial samples—from low-GC bacterial isolates to complex metagenomic communities.

High-Throughput Multiplexing Enables Scale

Cost-effective sequencing of hundreds of samples simultaneously with advanced multiplexing capabilities for large-scale metagenomic studies.

Precision Analysis for Publication-Ready Data

Detect low-frequency single nucleotide polymorphisms (SNPs), insertions/deletions (InDels), and structural variants (SVs) with comprehensive genomic analysis. Rigorous quality control using three controls per batch—a negative control and two reference standards—ensures reliable, reproducible data.

Proven Expertise in Microbial Genomics

Leverage our 30+ years of sequencing expertise, proven workflows, comprehensive quality control protocols, and dedicated specialists to support your most demanding microbial research projects.

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Research Applications

Pathogen & Disease Research

  • Antibiotic resistance monitoring and surveillance
  • Drug discovery
  • Novel species identification and characterization

Evolutionary & Comparative Genomics

  • Large-scale evolutionary studies and phylogenetic analysis
  • Population genetics and genetic diversity assessment

Microbiome & Environmental Studies

  • Metagenomic community analysis and profiling
  • Host-microbe interaction studies
  • Agricultural and soil microbiome analysis

Microbial Whole Genome Sequencing with Broad Clinical Labs

Service or tier/type Data Deliverables What’s Included

Tagmentation-based
Large/complex bacterial
community metagenomics
  • FASTQ file
  • ~3 Gb data output per sample
  • Sample receipt & incoming QC
  • Library construction & QC
  • Multiplexing
  • 2×151 bp paired-end sequencing
  • Data delivery

Tagmentation-based
Large genome bacterial
isolates
  • FASTQ file
  • ~3 Gb data output per sample
  • Sample receipt & incoming QC
  • Library construction & QC
  • Multiplexing
  • 2×151 bp paired-end sequencing
  • Data delivery

Non-tagmentation-based
Low GC content isolates
  • FASTQ file
  • ~3 Gb data output per sample
  • Sample receipt & incoming QC
  • Library construction & QC
  • 2×151 bp paired-end sequencing
  • Data delivery

Project Workflow- Microbial Whole Genome Sequencing

Project onboarding

Project onboarding
(contracting if required)

Regulatory Review
Quoting
Sample Kits

Expedited data generation and delivery available for some sample types

Sample intake and QC

Sample intake and QC
(extraction optional)

Receipt
Incoming Sample QC

Library Receipt at BCL

Library construction

Tagmentation- and non-tagmentation-based methods available, depending upon sample type

Sequencing

Sequencing

NovaSeq 6000 SP or S4 flow cell

Data delivery

Data and report delivery
(bioinformatic analysis optional)

FASTQ files

Data delivered via secure
cloud-based platform

Project onboarding

Project onboarding
(contracting if required)

Regulatory Review
Quoting
Sample Kits

Expedited data generation and delivery available for some sample types

Sample intake and QC

Sample intake and QC
(extraction optional)

Receipt
Incoming Sample QC

Library Receipt at BCL

Library construction

Tagmentation- and non-tagmentation-based methods available, depending upon sample type

Sequencing

Sequencing

NovaSeq 6000 SP or S4 flow cell

Data delivery

Data and report delivery
(bioinformatic analysis optional)

FASTQ files

Data delivered via secure
cloud-based platform

Contact our team today to discuss your microbial genomics project.

Begin Your Microbial WGS Project

Looking for somatic sequencing? See our Human Whole Genome Sequencing service.

Human Whole Genome Sequencing